Radiographic predictors of occult intracranial involvement in olfactory neuroblastoma patients-Reference-Cited by-同舟云学术

Radiographic predictors of occult intracranial involvement in olfactory neuroblastoma patients

Published:2023-03-13 Issue:10 Volume:13 Page:1876-1888
ISSN:2042-6976
Container-title:International Forum of Allergy & Rhinology
language:en
Short-container-title:Int Forum Allergy Rhinol

Author:

Geltzeiler Mathew¹,Choby Garret W.²³^ORCID,Ji Keven Seung Yong¹,JessMace C.¹,Almeida Joao Paulo⁴,de Almeida John⁵,Champagne Pierre‐Olivier⁶,Chan Erik⁷,Ciporen Jeremy N.⁸,Chaskes Mark B.⁹,Cornell Sarah¹⁰,Drozdowski Veronica¹¹,Fernandez‐Miranda Juan¹²,Gardner Paul A.¹³,Hwang Peter H.⁷,Kalyvas Aristotelis⁵,Kong Keonho A.⁹,McMillan Ryan A.²^ORCID,Nayak Jayakar V.⁷^ORCID,Patel Chirag¹¹,Patel Zara M.⁷^ORCID,Celda Maria Peris²³,Pinheiro‐Neto Carlos²³,Sanusi Olabisi R.⁸,Snyderman Carl H.¹⁴^ORCID,Thorp Brian D.⁹,Van Gompel Jamie J.²³,Zadeh Gelareh⁵,Zenonos Georgios¹³,Zwagerman Nathan T.¹⁰,Wang Eric W.¹⁴^ORCID

Affiliation:

1. Department of Otolaryngology‐Head and Neck Surgery Oregon Health & Science University Portland Oregon USA

2. Department of Otolaryngology‐Head and Neck Surgery Mayo Clinic Rochester Minnesota USA

3. Department of Neurological Surgery Mayo Clinic Rochester Minnesota USA

4. Department of Neurological Surgery Mayo Clinic Jacksonville Florida USA

5. Department of Surgery University of Toronto Ontario Canada

6. Department of Neurological Surgery Universite Laval Quebec Canada

7. Department of Otolaryngology‐Head and Neck Surgery Stanford University Palo Alto California USA

8. Department of Neurological Surgery Oregon Health & Science University Portland Oregon USA

9. Department of Otolaryngology‐Head and Neck Surgery University of North Carolina Chapel Hill North Carolina USA

10. Department of Neurological Surgery Medical College of Wisconsin Milwaukee Wisconsin USA

11. Department of Otolaryngology‐Head and Neck Surgery Loyola University Medical Center Maywood Illinois USA

12. Department of Neurological Surgery Stanford University Palo Alto California USA

13. Department of Neurological Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA

14. Department of Otolaryngology‐Head and Neck Surgery University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA

Abstract

AbstractBackgroundTraditional management of olfactory neuroblastoma (ONB) includes margin‐negative resection with removal of cribriform plate, dura, and olfactory bulb, regardless of intracranial disease. This approach may be overtreating certain patients. Our investigation examines risk factors associated with occult intracranial disease to optimize therapeutic outcomes.MethodsThis retrospective, multi‐institutional cohort study examined clinical covariates associated with occult intracranial involvement. Patient demographics, staging, Hyam's grade, and pathologic involvement of dura, olfactory bulb/tract, and brain were collected. Diagnostic imaging was reviewed. Positive and negative predictive value (NPV) were estimated along with effect size estimates. Cox hazard regression examined associations with overall survival (OS) and disease‐free survival (DFS).ResultsA total of 224 subjects with new diagnoses of ONB (2005–2021) were identified. Skull base bone involvement on computed tomography (CT) had the highest NPV for pathologic dura (88.0%), olfactory bulb (88%), and brain involvement (97.3%). Hyam's grade category was significantly associated with dural involvement (φC = 0.26; 95% confidence interval [CI]: 0.16, 0.42). Subjects without radiologic skull base involvement (n = 66) had pathologic positivity of 12.1%. Within this subgroup, Hyam's grade was clinically significant for dural positivity (φ = 0.34; 95% CI: −0.12, 0.71) with 28.6% involvement in high grade tumors. Neither clinical nor pathologic positivity of intracranial structures were associated with significantly different OS or DFS.ConclusionsBoth CT and magnetic resonance imaging (MRI) had reasonably good NPV for involvement of dura and olfactory bulb. Higher Hyam's grade was associated with dural involvement. Patients with low‐grade tumors not involving the skull base may be suitable for avoiding skull base resection; however, further investigation is warranted.

Publisher

Wiley

Subject

Otorhinolaryngology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alr.23145

Reference41 articles.

1. A rare case report of mixed olfactory neuroblastoma: Carcinoma with review of literature

2. Olfactory neuroblastoma (esthesioneuroblastoma): towards minimally invasive surgery and multi‐modality treatment strategies – an updated critical review of the current literature;Papacharalampous GX;JBUON,2013

3. Chemotherapy for Esthesioneuroblastomas

4. Endoscopic versus open craniofacial resection of esthesioneuroblastoma: What is the evidence?

5. Esthesioneuroblastoma: Results and Outcomes of a Single Institution's Experience