Ultra-performance liquid chromatography-tandem mass spectrometry assay for determination of plasma nomegestrol acetate and estradiol in healthy postmenopausal women

Author:

Nair Sneha G.1,Patel Daxesh P.12,Sanyal Mallika3,Singhal Puran4,Shrivastav Pranav S.1ORCID

Affiliation:

1. Department of Chemistry, School of Sciences; Gujarat University; Ahmedabad Gujarat India

2. Laboratory of Metabolism, Center for Cancer Research; National Cancer Institute; Bethesda Maryland USA

3. Department of Chemistry; St. Xavier's College; Ahmedabad Gujarat India

4. Bioanalytical Department; Alkem Laboratories Ltd; Mumbai India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference36 articles.

1. Effects of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in comparison to one containing levonorgestrel and ethinylestradiol on markers of endocrine function;Ågren;The European Journal of Contraception and Reproductive Health Care,2011

2. Nomegestrol acetate-17b-estradiol for oral contraception;Burke;Patient Preference and Adherence,2013

3. European Medicines Agency 2011 Committee for Medicinal Products for Human Use, Guidelines on Validation of Bioanalytical Methods (draft), EMA/CMP/EWP/192217/2009 www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

4. Enzyme immunoassay for nomegestrol acetate in human plasma;Ezan;The Journal of Steroid Biochemistry and Molecular Biology,1993

5. Derivatization of estrogens enhances specificity and sensitivity of analysis of human plasma and serum by liquid chromatography tandem mass spectrometry;Faqehi;Talanta,2016

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