Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications-Reference-Cited by-同舟云学术

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications

Published:2020-07-09 Issue:1 Volume:109 Page:55-64
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Zamek‐Gliszczynski Maciej J.¹,Patel Mitesh²,Yang Xinning³,Lutz Justin D.⁴,Chu Xiaoyan⁵,Brouwer Kim L. R.⁶^ORCID,Lai Yurong⁷^ORCID,Lee Caroline A.⁸,Neuhoff Sibylle⁹,Paine Mary F.¹⁰^ORCID,Sugiyama Yuichi¹¹^ORCID,Taskar Kunal S.¹²^ORCID,Galetin Aleksandra¹³^ORCID

Affiliation:

1. Drug Meabolism and PharmacokineticsGlaxoSmithKline Collegeville Pennsylvania USA

2. Pharmacokinetics and Drug Metabolism Amgen Research Cambridge Massachusetts USA

3. Office of Clinical Pharmacology US Food and Drug Administration Silver Spring Maryland USA

4. Department of Clinical Pharmacology Gilead Sciences, Inc Foster City California USA

5. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism Merck & CO.Inc, Kenilworth New Jersey USA

6. Division of Pharmacotherapy and Experimental Therapeutics UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina USA

7. Drug Metabolism Gilead Sciences, Inc. Foster City California USA

8. Nonclinical Development and Clinical Pharmacology Arena Pharmaceuticals San Diego California USA

9. Simcyp DivisionCertara UK Limited Sheffield UK

10. Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane Washington USA

11. Sugiyama Laboratory RIKEN Baton Zone, Program RIKEN Cluster for Science RIKEN Yokohama Kanagawa Japan

12. Drug Meabolism and Pharmacokinetics GlaxoSmithKline Ware UK

13. Centre for Applied Pharmacokinetic Research School of Health Sciences The University of Manchester Manchester UK

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1916

Reference25 articles.

1. Beyond Competitive Inhibition: Regulation of ABC Transporters by Kinases and Protein-Protein Interactions as Potential Mechanisms of Drug-Drug Interactions

2. Complementary Stimulation of Hepatobiliary Transport and Detoxification Systems by Rifampicin and Ursodeoxycholic Acid in Humans

3. Induction of Influx and Efflux Transporters and Cytochrome P450 3A4 in Primary Human Hepatocytes by Rifampin, Rifabutin, and Rifapentine

4. Organic Anion-Transporting Polypeptide Genes Are Not Induced by the Pregnane X Receptor Activator Rifampin: Studies in Hepatocytes In Vitro and in Monkeys In Vivo

5. The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

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