Tritiation of azido-labeled diiodo cabazitaxel (Jevtana) and docetaxel (Taxotere) derivatives to generate 3 H-photoaffinity probes

Author:

Jones Seth1ORCID,Weck Remo1,Burhop Annina1,Atzrodt Jens1,Derdau Volker1ORCID

Affiliation:

1. SANOFI R&D, Integrated Drug Discovery; Sanofi-Aventis Deutschland GmbH; Frankfurt am Main Germany

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology, Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference45 articles.

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2. [3H]Chlorpromazine photolabeling of thetorpedonicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel;Chiara;Biochemistry,2009

3. Irreversible photolabeling of active site of neutral endopeptidase-24.11 “enkephalinase” by azidothiorphan and [14C]-azidothiorphan;Beamont;Mol Pharmacol,1987

4. Photochemical fishing approaches for identifying target proteins and elucidating the structure of a ligand-binding region using carbene-generating photoreactive probes;Sadakane;Anal Sci,2006

5. Cabazitaxel: a novel second-line treatment for metastatic castration-resistant prostate cancer;Channing;Drug Des, Dev Ther,2011

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