Experimental Schistosoma haematobium pulmonary hypertension

Author:

Kassa Biruk12,Fonseca‐Balladares Dara C.12,Kumar Rahul12,Lee Michael H.12ORCID,Mickael Claudia3,Sanders Linda3,Nolan Kevin12,Graham Brian B.12ORCID

Affiliation:

1. Department of Medicine Lung Biology Center, Zuckerberg San Francisco General Hospital San Francisco California USA

2. Department of Medicine University of California San Francisco San Francisco California USA

3. Department of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA

Abstract

AbstractWhether all Schistosoma species cause pulmonary hypertension (PH) is unclear. Experimentally exposing mice to Schistosoma haematobium eggs caused PH, which was less severe than that induced by S. mansoni exposure. These findings align with the relatively uncommon reports of pulmonary arterial hypertension associated with S. haematobium.

Funder

American Heart Association

Congressionally Directed Medical Research Programs

American Thoracic Society

Cardiovascular Medical Research and Education Fund

National Heart, Lung, and Blood Institute

United Therapeutics Corporation

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine

Reference18 articles.

1. Schistosomiasis Pulmonary Arterial Hypertension

2. Schistosomiasis-associated pulmonary arterial hypertension: a systematic review

3. [Pulmonary arterial hypertension due to bilharziasis. Apropos of a case due to Schistosoma haematobium having been cured by praziquantel];Bourée P;Bull Soc Pathol Exot,1990

4. Cor pulmonale due to chronic infestation with Schistosoma haematobium;Damluji SF;J Trop Med Hyg,1964

5. Hepatic Shunting of Eggs and Pulmonary Vascular Remodeling inBmpr2+/−Mice with Schistosomiasis

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