Simultaneous determination of skimmin, apiosylskimmin, 7‐hydroxycoumarin and 7‐hydroxycoumarin glucuronide in rat plasma by liquid chromatography–Orbitrap mass spectrometry and its application to pharmacokinetics

Author:

Luo Lijun12,Liu Xiao12ORCID,Jin Xiaoxu12,Liu Yuke12,Ma Jie34,Zhang Sen45,Zhang Dongming34,Chen Xiaoguang45,Sheng Li12,Li Yan12

Affiliation:

1. Department of Drug Metabolism, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China

2. Beijing Key Laboratory of Non‐Clinical Drug Metabolism and PK/PD Study, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China

3. Beijing Key Laboratory of Active Substances Discovery and Drug Ability Evaluation, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China

4. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China

5. Department of Pharmacology, Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

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