Affiliation:
1. Department of Radiation Oncology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou P. R. China
2. Zhongshan School of Medicine Sun Yat‐sen University Guangzhou P. R. China
3. Department of Radiation Oncology Sixth Affiliated Hospital, Kunming Medical University Yuxi Yunan China
4. Department of Medical Statistics and Epidemiology, School of Public Health Sun Yat‐sen University Guangzhou P. R. China
Abstract
AbstractBackground and AimsLeisure sedentary behavior (LSB) is associated with the risk of cancer, but the causal relationship between them has not been clarified. The aim of this study was to assess the potential causal association between LSB and risk of 15 site‐specific cancers.MethodsThe causal association between LSB and cancer were assessed with univariate Mendelian randomization (UVMR) and multivariate Mendelian randomization (MVMR). 194 SNPs associated with LSB (from the UK Biobank 408,815 individuals) were adopted as the instrument variables. Sensitivity analyses were performed to ensure the robustness of the results.ResultsUVMR analysis revealed that television watching significantly increased the risk of endometrial cancer (OR = 1.29, 95% CI = 1.02–1.64, p = 0.04) (mainly the endometrioid histology [OR = 1.28, 95% CI = 1.02–1.60, p = 0.031]),breast cancer (OR = 1.16, 95% CI = 1.04–1.30, p = 0.007) (both ER+ breast cancer [OR = 1.17, 95% CI = 1.03–1.33, p = 0.015], and ER− breast cancer [OR = 1.55, 95% CI = 1.26–1.89, p = 2.23 × 10−5]). Although causal association was not found between television watching and ovarian cancer, it was seen in low grade and low malignant potential serous ovarian cancer (OR = 1.49, 95% CI = 1.07–2.08, p = 0.018). However, significant results were not obtained in the UVMR analysis between driving, computer use and the 15 types of cancer. Further MVMR analysis indicated that the above results are independent from most metabolic factors and dietary habits, but mediated by educational attainment.ConclusionLSB in form of television watching has independent causal association with the risk of endometrial cancer, breast cancer, and ovarian cancer.
Funder
National Natural Science Foundation of China
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology
Cited by
2 articles.
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