Affiliation:
1. Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA
2. Department of Radiology Brigham and Women's Hospital Boston Massachusetts USA
3. Department of Neurology Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts USA
Abstract
AbstractBackgroundMagnetic resonance guided focused ultrasound (MRgFUS) is United States Food and Drug Administration approved for the treatment of tremor‐dominant Parkinson's disease (TdPD), but only limited studies have been described in practice.ObjectivesTo report the largest prospective experience of unilateral MRgFUS thalamotomy for the treatment of medically refractory TdPD.MethodsClinical outcomes of 48 patients with medically refractory TdPD who underwent MRgFUS thalamotomy were evaluated. Tremor outcomes were assessed using the Fahn‐Tolosa‐Marin scale and adverse effects were categorized using a structured questionnaire and clinical exam at 1 month (n = 44), 3 months (n = 34), 1 year (n = 22), 2 years (n = 5), and 3 years (n = 2). Patients underwent magnetic resonance imaging <24 hours post‐procedure.ResultsSignificant tremor control persisted at all follow‐ups (P < 0.001). All side effects were mild. At 3 months, these included gait imbalance (38.24%), sensory deficits (26.47%), motor weakness (17.65%), dysgeusia (5.88%), and dysarthria (5.88%), with some persisting at 1 year.ConclusionsMRgFUS thalamotomy is an effective treatment for sustained tremor control in patients with TdPD. © 2023 International Parkinson and Movement Disorder Society.
Subject
Neurology (clinical),Neurology
Cited by
1 articles.
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