Cotransporting Ion is a Trigger for Cellular Endocytosis of Transporter-Targeting Nanoparticles: A Case Study of High-Efficiency SLC22A5 (OCTN2)-Mediated Carnitine-Conjugated Nanoparticles for Oral Delivery of Therapeutic Drugs-Reference-Cited by-同舟云学术

Cotransporting Ion is a Trigger for Cellular Endocytosis of Transporter-Targeting Nanoparticles: A Case Study of High-Efficiency SLC22A5 (OCTN2)-Mediated Carnitine-Conjugated Nanoparticles for Oral Delivery of Therapeutic Drugs

Published:2017-06-29 Issue:17 Volume:6 Page:1700165
ISSN:2192-2640
Container-title:Advanced Healthcare Materials
language:en
Short-container-title:Adv. Healthcare Mater.

Author:

Kou Longfa¹²,Yao Qing¹,Sun Mengchi¹,Wu Chunnuan³,Wang Jia¹,Luo Qiuhua¹,Wang Gang¹,Du Yuqian¹,Fu Qiang¹,Wang Jian⁴,He Zhonggui⁵,Ganapathy Vadivel²,Sun Jin¹

Affiliation:

1. Municipal Key Laboratory of Biopharmaceutics; School of Pharmacy; Shenyang Pharmaceutical University; No. 103 Wenhua Road Shenyang 110016 China

2. Department of Cell Biology and Biochemistry; Texas Tech University Health Sciences Center; Lubbock TX 79430 USA

3. Tianjin Medical University Cancer Institute & Hospital; Tianjin 300060 China

4. Key Laboratory of Structure-Based Drug Design and Discovery; Shenyang Pharmaceutical University; Ministry of Education; Shenyang 110016 China

5. Department of Pharmaceutics; School of Pharmacy; Shenyang Pharmaceutical University; Shenyang 110016 China

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Welch Endowed Chair in Biochemistry

Texas Tech University

China Scholarship Council

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

Reference30 articles.

1. Transport of Valganciclovir, a Ganciclovir Prodrug, via Peptide Transporters PEPT1 and PEPT2

2. Valacyclovir: A Substrate for the Intestinal and Renal Peptide Transporters PEPT1 and PEPT2

3. Prodrug Design Targeting Intestinal PepT1 for Improved Oral Absorption: Design and Performance

4. Drug transport via the intestinal peptide transporter PepT1

5. Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

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