A pilot study of electronic directly observed therapy to improve hydroxyurea adherence in pediatric patients with sickle-cell disease

Author:

Creary Susan E.1,Gladwin Mark T.2,Byrne Melissa3,Hildesheim Mariana4,Krishnamurti Lakshmanan5

Affiliation:

1. Division of Pediatric Hematology-Oncology; Nationwide Children's Hospital; Columbus Ohio

2. Division of Pulmonary, Allergy, Critical Care Medicine, Vascular Medicine Institute; University of Pittsburgh; Pittsburgh Pennsylvania

3. Division of Pediatric Hematology-Oncology; Children's Hospital of Pittsburgh of UPMC; Pittsburgh Pennsylvania

4. Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine; University of Pittsburgh; Pittsburgh Pennsylvania

5. Division of Hematology/Oncology; Children's Hospital of Pittsburgh of UPMC; Pittsburgh Pennsylvania

Funder

Health Resources and Services Administration (HRSA)

Hemostasis and Vascular Medicine Institute

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Reference28 articles.

1. National Heart, Lung, and Blood Institute, Disease and Conditions Index: Sickle cell anemia: Who is at risk http://www.nhlbi.nih.gov/health/health-topics/topics/sca/atrisk.html

2. Mortality in sickle cell disease: Life expectancy and risk factors for early death;Platt;N Eng J Med,1994

3. Therapy preference and decision-making among patients with severe sickle cell anemia and their families;Hankins;Pediatr Blood Cancer,2007

4. Hydroxyurea induces fetal hemoglobin by the nitric oxide-dependent activation of soluble guanylyl cyclase;Cokic;J Clin Invest,2003

5. Long-term hydroxyurea therapy for infants with sickle cell anemia: The HUSOFT extension study;Hankins;Blood,2005

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