Affiliation:
1. Department of Chemistry Indian Institute of Technology Patna Bihta Bihar India
2. Biological Engineering Discipline Indian Institute of Technology Gandhinagar Palaj Gujarat India
Abstract
Syntheses of five (1–5) cationic organometallic complexes bearing two platinum (II) centers are being reported. Compounds 1 and 2 have a flexible molecular backbone and are isomeric. Compounds 3, 4, and 5 are structural isomers with a rigid structural framework and containing pyrimidine/pyrazine in the center and two pendant arms bearing the alkynyl–ditopic platinum units. Compounds 1–5 were systematically characterized using FT‐IR, NMR [1H, 31P{1H}, and 13C{1H}], and HRMS. The antiproliferative activity of these compounds was examined against HeLa cancer cell line, and results were compared with that of cisplatin. “Live/dead” cell death assay was performed to ratify the superior antiproliferative activities of some of these organometallic complexes with respect to cisplatin.
Subject
Inorganic Chemistry,General Chemistry