A phase I/Ib trial targeting the Pi3k/Akt pathway using perifosine: Long-term progression-free survival of patients with resistant neuroblastoma

Author:

Kushner Brian H.1,Cheung Nai-Kong V.1,Modak Shakeel1,Becher Oren J.2,Basu Ellen M.1,Roberts Stephen S.1,Kramer Kim1,Dunkel Ira J.1

Affiliation:

1. Department of Pediatrics; Memorial Sloan Kettering Cancer Center; New York NY

2. Department of Pediatrics; Duke University Medical Center; Durham NC

Funder

NIH/NCI Cancer Center Support Grant

Gerber Foundation, Fremont, MI; the Robert Steel Foundation, New York, NY; Katie's Find A Cure Fund, New York, NY

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference25 articles.

1. Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review);Nitulescu;Int J Oncol,2016

2. The PI3K pathway as drug target in human cancer;Courtney;J Clin Oncol Off J Am Soc Clin Oncol,2010

3. A phase I trial of perifosine (NSC 639966) on a loading dose/maintenance dose schedule in patients with advanced cancer;Ummersen;Clin Cancer Res Off J Am Assoc Cancer Res,2004

4. A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms;Figg;Cancer Chemother Pharmacol,2014

5. Emerging treatment options for the treatment of neuroblastoma: potential role of perifosine;Sun;OncoTargets Ther,2012

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