A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice

Author:

Koh Mei Yee1,Gagea Mihai2,Sargis Timothy1,Lemos Robert1,Grandjean Geoffrey1,Charbono Adriana1,Bekiaris Vasileos1,Sedy John1,Kiriakova Galina2,Liu Xiuping2,Roberts Lewis R.3,Ware Carl1,Powis Garth1

Affiliation:

1. Sanford Burnham Prebys Medical Discovery Institute; La Jolla CA

2. The University of Texas M.D. Anderson Cancer Center; Houston TX

3. Mayo Clinic; Rochester MN

Funder

Mayo Clinic Cancer Center

SBP NCI Cancer Center

Publisher

Wiley

Subject

Hepatology

Reference34 articles.

1. Hypoxia-inducible factors as essential regulators of inflammation;Imtiyaz;Curr Topics Microbiol Immunol,2010

2. Passing the baton: the HIF switch;Koh;Trends Biochem Sci,2012

3. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension;Wang;Proc Natl Acad Sci U S A,1995

4. HIF-1α is essential for myeloid cell-mediated inflammation;Cramer;Cell,2003

5. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation;Jaakkola;Science,2001

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