Affiliation:
1. Department of Endocrinology and Metabolism Tokyo Shinagawa Hospital Tokyo Japan
2. Department of Respiratory Medicine Tokyo Shinagawa Hospital Tokyo Japan
3. Department of Gastroenterology Tokyo Shinagawa Hospital Tokyo Japan
Abstract
AbstractBackground and AimIncreased liver fibrosis scores (LFS), such as fibrosis‐4 index (FIB‐4) or non‐alcoholic fatty liver disease fibrosis score (NFS), and fatty liver are known risk factors for severe coronavirus disease 2019 (COVID‐19). The purpose of this study was to identify the best scores, which predict the prognosis of COVID‐19.MethodsParticipants comprised consecutive Japanese COVID‐19 patients admitted to our hospital between February 14, 2020, and April 14, 2021. Multivariate logistic regression analysis was performed to evaluate the relationships between LFS (FIB‐4, NFS, aspartate aminotransferase‐to‐platelet ratio index [APRI], BARD score, and hepatic steatosis index [HSI]) or fatty liver on computed tomography (CT), and severity of COVID‐19.ResultsOf the 415 patients (mean age, 59 years), 177 patients (42.7%) needed oxygen therapy, 90 patients (21.7%) worsened to severe COVID‐19, and 45 patients (10.8%) died during admission. Multivariate logistic regression analysis showed that increased FIB‐4 and NFS were risk factors for death, severe COVID‐19, and oxygen demand; that increased BARD was a risk factor for severe COVID‐19 and oxygen demand; and that increased APRI and HSI were not risk factors for any status of COVID‐19. Furthermore, increased NFS or BARD and fatty liver were independent risk factors for severe COVID‐19 and oxygen demand.ConclusionsThis study showed that FIB‐4 and NFS were the best liver fibrosis scores that predicted worse prognosis for COVID‐19, and that increased NFS or BARD and fatty liver evident on CT represented independent risk factors for severe COVID‐19 and oxygen demand.
Reference44 articles.
1. WHO.Coronavirus disease (COVID‐19) dashboard. Available from URL:https://covid19.who.intAccessed on November 16 2023.
2. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China
3. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study
4. Underlying Medical Conditions Associated with Higher Risk for Severe COVID‐19: Information for Healthcare Professionals.Centers for Disease Control and Prevention Georgia USA. Available from URL:https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/underlyingconditions.htmlAccessed on May 23 2023.
5. Non-alcoholic fatty liver diseases in patients with COVID-19: A retrospective study