Synthesis, preclinical, and pharmacokinetic evaluation of a new zoledronate derivative as a promising antiosteoporotic candidate using radiolabeling technique

Author:

Motaleb H.A.1ORCID,Ibrahim Ismail Taha1,El-Tawoosy M.1,Mohamed M.I.2

Affiliation:

1. Hot Labs. Center, Atomic Energy Authority; Cairo Egypt

2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy; Cairo University; Giza Egypt

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Radiology Nuclear Medicine and imaging,Biochemistry,Analytical Chemistry

Reference34 articles.

1. Bisphosphonates: mechanism of action and role in clinical practice;Drake;Mayo Clin Proc,2008

2. Mechanisms of action of etidronate and other bisphosphonates;Ebetino;Rev Contemp Pharmacother,1998

3. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy, International Osteoporosis Foundation and National Osteoporosis Foundation;Russell;Osteoporos Int,2008

4. Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo;Hughes;J Bone Miner Res,1995

5. Characteristics of clodronate-induced apoptosis in osteoclasts and macrophages;Selander;Mol Pharmacol,1996

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