The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals-Reference-Cited by-同舟云学术

The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals

Published:2021-12-08 Issue: Volume: Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Salvadó Gemma¹²^ORCID,Ferreira Daniel³⁴^ORCID,Operto Grégory¹²⁵^ORCID,Cumplido‐Mayoral Irene¹⁶^ORCID,Arenaza‐Urquijo Eider M.¹²⁵^ORCID,Cacciaglia Raffaele¹²⁵^ORCID,Falcon Carles¹²⁷^ORCID,Vilor‐Tejedor Natàlia¹⁶⁸⁹^ORCID,Minguillon Carolina¹²⁵^ORCID,Groot Colin¹⁰^ORCID,Flier Wiesje M.¹⁰¹¹^ORCID,Barkhof Frederik¹²¹³^ORCID,Scheltens Philip¹⁰^ORCID,Ossenkoppele Rik¹⁰¹⁴^ORCID,Kern Silke¹⁵,Zettergren Anna¹⁵,Skoog Ingmar¹⁵^ORCID,Hort Jakub¹⁶¹⁷,Stomrud Erik¹⁸¹⁹^ORCID,Westen Danielle²⁰²¹^ORCID,Hansson Oskar¹⁸¹⁹^ORCID,Molinuevo José Luis¹^ORCID,Wahlund Lars‐Olof³^ORCID,Westman Eric³²²^ORCID,Gispert Juan Domingo¹²⁶⁷^ORCID,

Affiliation:

1. Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain

2. IMIM (Hospital del Mar Medical Research Institute) Barcelona Spain

3. Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden

4. Department of Radiology Mayo Clinic Rochester Minnesota USA

5. CIBER Fragilidad y Envejecimiento Saludable (CIBERFES) Madrid Spain

6. Universitat Pompeu Fabra Barcelona Spain

7. Centro de Investigación Biomédica en Red de Bioingeniería Biomateriales y Nanomedicina (CIBER‐BBN) Madrid Spain

8. Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology Barcelona Spain

9. Department of Clinical Genetics ERASMUS MC Rotterdam the Netherlands

10. Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC Amsterdam the Netherlands

11. Department of Epidemiology & Biostatistics Amsterdam Neuroscience Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam the Netherlands

12. Department of Radiology and Nuclear Medicine VU Medical Center, Neuroscience Campus Amsterdam Amsterdam the Netherlands

13. Institutes of Neurology & Healthcare Engineering University College London London UK

14. Clinical Memory Research Unit Lund University Lund Sweden

15. Neuropsychiatric Epidemiology Unit Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg Gothenburg Sweden

16. International Clinical Research Centre St. Anne's University Hospital Brno Brno Czech Republic

17. Memory Clinic Department of Neurology Charles University, 2nd Faculty of Medicine and Motol University Hospital Prague Czech Republic

18. Department of Clinical Sciences Clinical Memory Research Unit Lund University Lund Sweden

19. Memory Clinic Skåne University Hospital Malmö Sweden

20. Diagnostic Radiology Institution for Clinical Sciences Lund University Lund Sweden

21. Image and Function Skåne University Hospital Lund Sweden

22. Department of Neuroimaging Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London London UK

Funder

Vetenskapsrådet

Hjärnfonden

Åke Wiberg Stiftelse

Stiftelsen Olle Engkvist Byggmästare

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/alz.12487

Reference43 articles.

1. Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

2. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

3. Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

4. Fibrillar amyloid- burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

5. Effects of APOE ‐ε4 allele load on brain morphology in a cohort of middle‐aged healthy individuals with enriched genetic risk for Alzheimer's disease;Cacciaglia R;Alzheimer's Dement,2018

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