Affiliation:
1. Research Unit in Virology and Cancer, Children's Hospital of Mexico Federico Gómez , Mexico City, Mexico
2. Postgraduate Program in Biological Science, National Autonomous University of Mexico , Mexico City, Mexico
Abstract
Abstract
β- and γ-herpesviruses persistently infect most of the world population, largely without clinical manifestations. However, in immunosuppressive settings like transplantation, these viruses are often jointly reactivated, associating with graft dysfunction/rejection, HCMV disease, and lymphoproliferation. In HIV/AIDS, direct interaction mechanisms have been described for EBV and KSHV in primary effusion lymphoma, demonstrating that the cooperation between both viruses enhances lymphomagenesis. Here, we discuss the clinical evidence supporting that the simultaneous reactivation of these viruses increases the probability of mutual interactions, also providing a conceptual framework explaining how one virus can influence another. Specifically, we propose mechanisms of indirect communication through immune soluble mediators, mainly cytokines, chemokines, and IFN regulatory molecules, based on common features of their infectious cycles and the convergent need on immunomodulatory mechanisms. This latter point should be experimentally addressed in feature research.
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Immunology,Immunology and Allergy
Reference144 articles.
1. Herpesvirus;Bascones-Martínez;Avances en Odontoestomatología,2011
2. Herpes virus 8: Sarcoma de Kaposi, enfermedad de Castleman y linfoma de efusión primario;Barba;Revista Latinoamericana de Patología Clínica y Medicina de Laboratorio,2012
3. Epstein-barr virus and kaposi's sarcoma herpesvirus/human herpesvirus 8;Proceedings of the IARC Working Group on the Evaluation of Carcinogenic Risks to Humans;IARC Monogr Eval Carcinog Risks Hum,1997
4. Oncomodulatory signals by regulatory proteins encoded by human cytomegalovirus: A novel role for viral infection in tumor progression;Cinatl;FEMS Microbiol Rev,2004
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献