Lisocabtagene maraleucel for treatment of relapsed and refractory primary mediastinal large B‐cell lymphoma in an adolescent patient

Author:

Lee Dasom1ORCID,Goyal Anmol2,Wang William L1,Ananth Snegha2,Lau Eric3,Binkley Michael S4ORCID,Bharadwaj Sushma2ORCID,Dahiya Saurabh2ORCID

Affiliation:

1. Division of Hematology Stanford University School of Medicine Stanford California USA

2. Division of Blood and Marrow Transplantation and Cellular Therapy Stanford University School of Medicine Stanford California USA

3. Department of Hematology and Oncology Palo Alto Foundation Medical Group Palo Alto California USA

4. Department of Radiation Oncology Stanford University School of Medicine Stanford California USA

Abstract

AbstractThe safety and efficacy of CAR T‐cell therapy are unknown in pediatric and adolescent patients with relapsed or refractory primary mediastinal large B‐cell lymphoma (R/R PMBCL) which is associated with dismal prognosis. Here, we present a case report of a 16‐year‐old patient with R/R PMBCL treated with lisocabtagene maraleucel including correlative studies. Patient achieved complete response at 6 months without cytokine release syndrome and immune effector cell‐associated neurotoxicity syndrome. She only experienced mild cytopenias, requiring filgrastim once. This report highlights the safety and efficacy of lisocabtagene maraleucel in this population, warranting prospective studies to improve clinical outcomes.

Publisher

Wiley

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Antineoplastics;Reactions Weekly;2024-03-23

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