Nickel allergy does not correlate with function after total knee arthroplasty

Author:

Chimento George1ORCID,Daher Jimmy1,Desai Bhumit1ORCID,Velasco‐Gomez Cruz1

Affiliation:

1. Department of Orthopaedic Surgery Ochsner Medical Center New Orleans Louisiana USA

Abstract

AbstractPurposeThe purpose of this study is to determine if there is a relationship between clinical outcomes and nickel allergy by evaluating asymptomatic total knee arthroplasty (TKA) patients with well‐functioning implants through quantitative metal allergy (MA) testing.MethodsA prospective case series was performed on 50 patients with well‐functioning TKA of various implant types. Inclusion criteria included primary TKA with a minimum 12‐month follow‐up and Oxford knee score (OKS) ≥ 40. A commercially available Lymphocyte Transformation Test measured the amount of a hypersensitivity lymphocyte immune response after exposure to a particular antigen. MA results were stratified based on the stimulation index (SI). The Cochran–Mantel–Haenzel test was used to test the homogeneity of metal reactivities. The Wilcoxon–Mann–Whitney test was used to compare individual metal SI by gender and the association of OKS and metal SI was ascertained with the Spearman correlation.ResultsNickel, cobalt, and chromium do not have the same reactivity scores (p < 0.001), and only nickel showed reactive/highly reactive scores. Females were found to have 3.41 times the odds of males for higher Ni reactivity (p = 0.0295, odds ratio [OR], 95% confidence interval [CI] = 3.41 [1.13–10.3]) only. Clinically, there was no correlation between metal SI and OKS score by metal (Ni rho = −0.1779; Co rho = −0.0036; Cr rho = −0.1748).ConclusionThis is the first study looking at MA in well‐functioning TKA. There is no correlation between clinical results and nickel reactivity. Surgeons should exercise caution when revising a painful or poorly functioning TKA based solely on a ‘positive’ Nickel Allergy test and look for other possible reasons for failure.Level of EvidenceLevel II.

Publisher

Wiley

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