Bcl-2 protects TK6 cells against hydroquinone-induced apoptosis through PARP-1 cytoplasm translocation and stabilizing mitochondrial membrane potential

Author:

Chen Yuting1,Chen Shaoyun1,Liang Hairong1,Yang Hui1,Liu Linhua1,Zhou Kairu1,Xu Longmei1,Liu Jiaxian1,Yun Lin1,Lai Bei1,Song Li1,Luo Hao1,Peng Jianming2,Liu Zhidong2,Xiao Yongmei3,Chen Wen3,Tang Huanwen1

Affiliation:

1. Department of Environmental and Occupational Health; Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University; Dongguan 523808 China

2. Huizhou Prevention and Treatment Centre for Occupational Disease; Huizhou 516000 China

3. Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment; Department of Toxicology, School of Public Health, Sun Yat-sen University; Guangzhou 510080 China

Funder

National Natural Science Foundation of China

Guangdong Provincial Natural Science Foundation, China

Key project of Science and Technology Program of Dongguan Bureau of Science and Technology, China

Science and Technology Program of Zhanjiang Bureau of Science and Technology, China

Science Foundation of Guangdong Medical University, China

Key Program of National Natural Science Foundation of China

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Genetics(clinical),Epidemiology

Reference60 articles.

1. Multiple subcellular localization of bcl-2: Detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes;Akao;Cancer Res,1994

2. The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks;Ali;Nat Struct Mol Biol,2012

3. DNA damage by hydroquinone in human white blood cells: Analysis by alkaline single-cell gel electrophoresis;Andreoli;Mutat Res,1999

4. The role of catechols and free radicals in benzene toxicity: An oxidative DNA damage pathway;Barreto;Environ Mol Mutagen,2009

5. The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells;Broecker-Preuss;Cancer Cell Int,2016

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