L-dopa increases α -synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro-Reference-Cited by-同舟云学术

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L-dopa increases α -synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro

Published:2015-07-14 Issue:13 Volume:30 Page:1794-1801
ISSN:0885-3185
Container-title:Movement Disorders
language:en
Short-container-title:Mov Disord.

Author:

Schmitt Ina¹²,Kaut Oliver¹,Khazneh Hassan¹,deBoni Laura¹,Ahmad Ashar³,Berg Daniela²⁴,Klein Christine⁵,Fröhlich Holger³,Wüllner Ullrich¹²

Affiliation:

1. Department of Neurology; UKB; Bonn Germany

2. German Center for Neurodegenerative Diseases (DZNE); Bonn Germany

3. Bonn-Aachen International Center for IT, University of Bonn; Germany

4. Department of Neurodegeneration; Hertie Institute for Clinical Brain Research; Tübingen Germany

5. Institute of Neurogenetics, University of Lübeck; Lübeck Germany

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/mds.26319/fullpdf

Reference28 articles.

1. Alpha-synuclein locus triplication causes Parkinson's disease;Singleton;Science,2003

2. Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease;Maraganore;JAMA,2006

3. Large-scale replication and heterogeneity in Parkinson disease genetic loci;Sharma;Neurology,2012

4. Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease;Gründemann;Nucleic Acids Res,2008

5. Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis;Nemani;Neuron,2010

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