DGKζ Downregulation Enhances Osteoclast Differentiation and Bone Resorption Activity Under Inflammatory Conditions

Author:

Iwazaki Kiyoshi12,Tanaka Toshiaki1,Hozumi Yasukazu1,Okada Masashi1,Tsuchiya Rieko1,Iseki Ken3,Topham Matthew K.4,Kawamae Kaneyuki5,Takagi Michiaki2,Goto Kaoru1

Affiliation:

1. Department of Anatomy and Cell Biology; Yamagata University School of Medicine; Yamagata Japan

2. Department of Orthopaedic; Yamagata University School of Medicine; Yamagata Japan

3. Department of Emergency and Critical Care Medicine; Yamagata University School of Medicine; Yamagata Japan

4. Department of Oncological Sciences, Huntsman Cancer Institute; University of Utah; Salt Lake City Utah

5. Department of Anesthesiology; Yamagata University School of Medicine; Yamagata Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Physiology

Reference41 articles.

1. Inhibition of diacylglycerol kinases as a physiological way to promote diacylglycerol signaling;Baldanzi;Adv Biol Regul,2014

2. Osteoclast differentiation and activation;Boyle;Nature,2003

3. RANKL-mediated osteoclast formation from murine RAW 264.7 cells;Collin-Osdoby;Methods Mol Med,2003

4. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet;de Chaffoy de Courcelles;J Biol Chem,1985

5. Phospholipid signaling;Divecha;Cell,1995

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