Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

Author:

Cohen Stanley B.,Cheng Tien-Tsai,Chindalore Vishala,Damjanov Nemanja,Burgos-Vargas Ruben,DeLora Patricia,Zimany Kathleen,Travers Helen,Caulfield John P.

Publisher

Wiley

Subject

Pharmacology (medical),Immunology,Rheumatology,Immunology and Allergy

Reference28 articles.

1. Pathway to the clinic: inhibition of p38 MAP kinase. A review of ten chemotypes selected for development;Goldstein;Curr Top Med Chem,2005

2. Novel pathways that regulate tumor necrosis factor-α production in rheumatoid arthritis;Gracie;Curr Opin Rheumatol,2002

3. Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases;Salituro;Curr Med Chem,1999

4. p38 MAPK signalling cascades in inflammatory disease;Herlaar;Mol Med Today,1999

5. Induction of cyclooxygenase-2 by the activated MEKK1→ SEK1/MKK4→p38 mitogen-activated protein kinase pathway;Guan;J Biol Chem,1998

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