Affiliation:
1. Department of Orthopaedics The Second Xiangya Hospital of Central South University Changsha Hunan China
2. Hunan Key Laboratory of Tumor Models and Individualized Medicine The Second Xiangya Hospital of Central South University Changsha Hunan China
3. Xiangya School of Medicine Central South University Changsha Hunan China
4. Department of Oncology The Second Xiangya Hospital of Central South University Changsha Hunan China
5. Shenzhen Research Institute of Central South University Guangdong China
6. Changsha Medical University Changsha China
Abstract
AbstractCancer is a major cause of death globally, and traditional treatments often have limited efficacy and adverse effects. Immunotherapy has shown promise in various malignancies but is less effective in tumors with low immunogenicity or immunosuppressive microenvironment, especially sarcomas. Tertiary lymphoid structures (TLSs) have been associated with a favorable response to immunotherapy and improved survival in cancer patients. However, the immunological mechanisms and clinical significance of TLS in malignant tumors are not fully understood. In this review, we elucidate the composition, neogenesis, and immune characteristics of TLS in tumors, as well as the inflammatory response in cancer development. An in‐depth discussion of the unique immune characteristics of TLSs in lung cancer, breast cancer, melanoma, and soft tissue sarcomas will be presented. Additionally, the therapeutic implications of TLS, including its role as a marker of therapeutic response and prognosis, and strategies to promote TLS formation and maturation will be explored. Overall, we aim to provide a comprehensive understanding of the role of TLS in the tumor immune microenvironment and suggest potential interventions for cancer treatment.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献