Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers
Author:
Affiliation:
1. Agios PharmaceuticalsInc. Cambridge MA USA
2. MBC Pharma Solutions Newtown PA USA
3. PAREXEL International Baltimore MD USA
4. Bruce A Silver Clinical Science and Development Dunkirk MD USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmaceutical Science
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpdd.604
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3. Erythrocyte Pyruvate Kinase Deficiency
4. Adenosine Triphosphate Depletion of Erythrocytes Simulates the Phenotype Associated with Pyruvate Kinase Deficiency and Confers Protection againstPlasmodium falciparumIn Vitro
5. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency
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