PD‐L1 expression in gastric and gastroesophageal junction cancer patients treated with perioperative chemotherapy

Author:

Ribeiro Héber S. C.1ORCID,Menezes Jacqueline N.1ORCID,da Costa Wilson L.12ORCID,F. de Jesus Victor Hugo3ORCID,Diniz Alessandro L.1,Godoy André L.1,de Farias Igor Correia1,Torres Silvio M.1ORCID,Neotti Tatiane4,Mello Celso A. L.3,Begnami Maria Dirlei F. S.5,Dias‐Neto Emmanuel6,Riechelmann Rachel P.3,Fernandez Coimbra Felipe José1

Affiliation:

1. Department of Abdominal Surgery A. C. Camargo Cancer Center São Paulo Brazil

2. Department of Medicine/Epidemiology and Population Sciences Baylor College of Medicine Houston Texas USA

3. Department of Clinical Oncology A. C. Camargo Cancer Center São Paulo Brazil

4. Department of Pathology A. C. Camargo Cancer Center São Paulo Brazil

5. Department of Surgical Pathology Hospital Sírio‐Libanês São Paulo Brazil

6. Laboratory of Medical Genomics A. C. Camargo Cancer Center São Paulo Brazil

Abstract

AbstractBackground and ObjectivesThe incidence, predictive, and prognostic impact of programmed cell death (PD‐L1) expression in gastric (GC) and gastroesophageal junction tumors (GEJC) treated with perioperative chemotherapy is poorly understood. We aimed to assess PD‐L1 expression by immunohistochemistry (IHC) in both pre and posttreatment specimens evaluating its impact on pathological response and survival outcomes.MethodsRetrospective cohort of patients with GC and GEJ tumors treated in a single western cancer center between 2007 and 2017. PD‐L1 expression was assessed by IHC before and after neoadjuvant chemotherapy, in surgical samples, and reported as combined positive score (CPS). CPS > 1% was tested for its association with pathological response and overall survival (OS).ResultsWe were able to assess PD‐L1 expression in at least one tissue sample from 155 subjects. PD‐L1 positivity rate was 20%. In 74 paired samples, a 21% discordance between PD‐L1 expression in biopsy sample and surgical specimen was observed. With a median follow‐up period of 60.3 months, 5‐years disease‐free survival was 60.5% with a median OS not reached. PD‐L1 expression was neither associated with pathological response or survival outcomes.ConclusionsPD‐L1 expression in the setting of locally advanced GC tumors was relatively low and can vary considering the tissue sample analyzed. This expression had no association with survival or pathological response in this population.

Funder

Cancer Prevention and Research Institute of Texas

Publisher

Wiley

Subject

Oncology,General Medicine,Surgery

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