Fundamental problems with pediatric adaptive dosing of carboplatin using nuclear‐medicine‐based estimates of renal function

Author:

Adamson Peter C.1ORCID,Veal Gareth J.2,Womer Richard B.1,Meany Holly J.3,Bernhardt M. Brooke4ORCID,Frazier A. Lindsay5ORCID,Balis Frank M.1ORCID

Affiliation:

1. Division of OncologyThe Children's Hospital of Philadelphia & Perelman School of MedicineUniversity of Pennsylvania Philadelphia Pennsylvania

2. Northern Institute for Cancer ResearchNewcastle University Newcastle upon Tyne UK

3. Department of Hematology/OncologyChildrens National Medical Center Washington District of Columbia

4. Department of PharmacyTexas Children's Hospital Houston Texas

5. Department of Pediatric OncologyDana‐Farber/Boston Children's Cancer and Blood Disorders CenterHarvard Medical School Boston Massachusetts

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology, and Child Health

Reference42 articles.

1. Prospective validation of a pharmacologically based dosing scheme for the cis‐diamminedichloroplatinum(II) analogue diamminecyclobutanedicarboxylatoplatinum;Egorin MJ;Cancer Res,1985

2. Pharmacokinetics and dosage reduction of cis‐diammine(1,1‐cyclobutanedicarboxylato)platinum in patients with impaired renal function;Egorin MJ;Cancer Res,1984

3. Carboplatin dosage: prospective evaluation of a simple formula based on renal function.

4. New Perspectives on an Old Friend: Optimizing Carboplatin for the Treatment of Solid Tumors

5. Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy

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