Activation of mTORC1 in B Lymphocytes Promotes Osteoclast Formation via Regulation of β-Catenin and RANKL/OPG

Author:

Xu Song12,Zhang Yue12,Liu Bin3,Li Kai1,Huang Bin2,Yan Bo2,Zhang Zhongmin2,Liang Kangyan1,Jia Chunhong1,Lin Jun1,Zeng Chun2,Cai Daozhang2,Jin Dadi2,Jiang Yu4,Bai Xiaochun12

Affiliation:

1. State Key Laboratory of Organ Failure Research; Department of Cell Biology; School of Basic Medical Sciences; Southern Medical University; Guangzhou China

2. Academy of Orthopedics in Guangdong Province; The Third Affiliated Hospital of Southern Medical University; Guangzhou China

3. Department of Spine Surgery; The Third Affiliated Hospital; Sun Yat-sen University; Guangzhou China

4. Department of Pharmacology and Chemical Biology; University of Pittsburgh School of Medicine; Pittsburgh PA USA

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference55 articles.

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4. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease;Kearns;Endocr Rev,2008

5. Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab;Lacey;Nat Rev Drug Discov,2012

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