Wnt/β‐Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease-Reference-Cited by-同舟云学术

Wnt/β‐Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease

Published:2019-12-31 Issue:5 Volume:71 Page:1732-1749
ISSN:0270-9139
Container-title:Hepatology
language:en
Short-container-title:Hepatology

Author:

Pradhan‐Sundd Tirthadipa¹,Kosar Karis¹,Saggi Harvinder¹,Zhang Rong¹,Vats Ravi²,Cornuet Pamela¹,Green Sydney³,Singh Sucha¹,Zeng Gang¹,Sundd Prithu²,Nejak‐Bowen Kari¹⁴^ORCID

Affiliation:

1. Department of Pathology University of Pittsburgh School of Medicine Pittsburgh PA

2. Vascular Medicine Institute University of Pittsburgh School of Medicine Pittsburgh PA

3. Morehouse School of Medicine Atlanta GA

4. Pittsburgh Liver Research Center University of Pittsburgh School of Medicine Pittsburgh PA

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Center for Research Resources

Publisher

Wiley

Subject

Hepatology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hep.30927

Reference38 articles.

1. Primary Sclerosing Cholangitis

2. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

3. Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

4. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

5. β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

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