The liver-gut microbiota axis modulates hepatotoxicity of tacrine in the rat

Author:

Yip Lian Yee12,Aw Chiu Cheong3,Lee Sze Han1,Hong Yi Shuen1,Ku Han Chen1,Xu Winston Hecheng1,Chan Jessalyn Mei Xuan1,Cheong Eleanor Jing Yi1,Chng Kern Rei4,Ng Amanda Hui Qi4,Nagarajan Niranjan4,Mahendran Ratha5,Lee Yuan Kun6,Browne Edward R.3,Chan Eric Chun Yong17

Affiliation:

1. Department of Pharmacy, Faculty of Science; National University of Singapore; Singapore Singapore

2. Metabolomics, Bioprocessing Technology Institute; Singapore Singapore

3. GSK Neural Pathways DPU; Singapore Singapore

4. Computational and Systems Biology; Genome Institute of Singapore; Singapore Singapore

5. Department of Surgery, Yong Loo Lin School of Medicine; National University of Singapore; Singapore Singapore

6. Department of Microbiology, Yong Loo Lin School of Medicine; National University of Singapore; Singapore Singapore

7. Singapore Institute for Clinical Sciences; Singapore Singapore

Funder

Agency for Science, Technology, and Research (A*STAR) Biomedical Research Council

National University of Singapore

GSK R&D Centre in Singapore

Science and Engineering Research Council

Publisher

Wiley

Subject

Hepatology

Reference49 articles.

1. Therapeutic modulation of microbiota-host metabolic interactions;Holmes;Sci Transl Med,2012

2. Host-gut microbiota metabolic interactions;Nicholson;Science,2012

3. Investigation of host-gut microbiota modulation of therapeutic outcome;Yip;Drug Metab Dispos,2015

4. Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism;Clayton;Proc Natl Acad Sci U S A,2009

5. Metabolism of foreign compounds by gastrointestinal microorganisms;Scheline;Pharmacol Rev,1973

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