Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor

Author:

Hassing H.A.12,Engelstoft M.S.23,Sichlau R.M.23,Madsen A.N.2,Rehfeld J.F.4,Pedersen J.5,Jones R.M.6,Holst J.J.57,Schwartz T.W.23,Rosenkilde M.M.2,Hansen H.S.1

Affiliation:

1. Department of Drug Design and Pharmacology; University of Copenhagen; Universitetsparken 2 Copenhagen Denmark

2. Laboratory for Molecular Pharmacology; Department of Neuroscience and Pharmacology, University of Copenhagen; Blegdamsvej 3 Copenhagen Denmark

3. Section for Metabolic Receptology and Enteroendocrinology; Novo Nordisk Foundation Center for Metabolic Research, University of Copenhagen; Blegdamsvej 3 Copenhagen 2200 Denmark

4. Department of Clinical Biochemistry; Rigshospitalet; Blegdamsvej Copenhagen Denmark

5. Department of Biomedical Science; Endocrinology Research Section, University of Copenhagen; Blegdamsvej 3 Copenhagen Denmark

6. Arena Pharmaceutical Inc; San Diego CA 92121 USA

7. Section for Translational Physiology, Novo Nordisk Foundation Center for Metabolic Research, Panum Institute; Blegdamsvej 3 Copenhagen Denmark

Publisher

Wiley

Subject

Clinical Biochemistry,Molecular Medicine,General Medicine,Biochemistry

Reference56 articles.

1. Absorption of monoacylglycerols by small intestinal brush border membrane;Schulthess;Biochemistry,1994

2. Formation and transport of chylomicrons by enterocytes to the lymphatics;Tso;Am. J. Physiol.,1986

3. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids;Briscoe;J. Biol. Chem.,2003

4. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120;Hirasawa;Nat. Med.,2005

5. 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans;Hansen;J. Clin. Endocrinol. Metab.,2011

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