In silico identified targeted inhibitors of P‐glycoprotein overcome multidrug resistance in human cancer cells in culture

Author:

Follit Courtney A.1,Brewer Frances K.1,Wise John G.1,Vogel Pia D.1

Affiliation:

1. Department of Biological Sciences The Center for Drug Discovery, Design and Delivery Southern Methodist University Dallas Texas 75275‐0376

Funder

National Institute of General Medical Sciences National Institutes of Health (NIH/NIGMS)

SMU University Research Council

SMU Dedman College Dean's Research Council

Dedman College Center for Drug Discovery, Design and Delivery (CD4)

Communities Foundation of Texas, Dallas

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference58 articles.

1. Mouse breast cancer resistance protein (Bcrp1/Abcg2) mediates etoposide resistance and transport, but etoposide oral availability is limited primarily by P‐glycoprotein;Allen JD;Cancer Res,2003

2. Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

3. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay;Alley MC;Cancer Res,1988

4. BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

5. In silico modelling of the interaction of flavonoids with human P-glycoprotein nucleotide-binding domain

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