Interactions between High Seroreactivity to Human Herpes Virus <scp>6A</scp> and Epstein–Barr Virus in <scp>MS</scp> Development: A Presymptomatic Case

Interactions between High Seroreactivity to Human Herpes Virus 6A and Epstein–Barr Virus in MS Development: A Presymptomatic Case–Control Study

Published:2024-06-11 Issue:2 Volume:96 Page:302-305
ISSN:0364-5134
Container-title:Annals of Neurology
language:en
Short-container-title:Annals of Neurology

Author:

Grut Viktor¹^ORCID,Biström Martin¹^ORCID,Salzer Jonatan¹,Stridh Pernilla²³^ORCID,Jons Daniel⁴^ORCID,Gustafsson Rasmus²³,Huang Jesse²³,Bergström Tomas⁵,Kockum Ingrid²³^ORCID,Waterboer Tim⁶,Olsson Tomas²³,Sundström Peter¹

Affiliation:

1. Department of Clinical Science, Neurosciences Umeå University Umeå Sweden

2. Department of Clinical Neuroscience Karolinska Institute Stockholm Sweden

3. Center for Molecular Medicine Karolinska University Hospital Stockholm Sweden

4. Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

5. Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

6. Infections and Cancer Epidemiology Division German Cancer Research Center Heidelberg Germany

Abstract

Synergistic interactions between human herpesvirus 6A (HHV‐6A) and Epstein–Barr virus (EBV) are hypothesized in the etiopathogenesis of multiple sclerosis (MS). This study investigated if HHV‐6A and EBV seroreactivities interact regarding the risk of developing MS. Antibodies against viral antigens were analyzed in biobank samples from 670 individuals who later developed MS and matched controls. Additive interactions were analyzed. A significant interaction between HHV‐6A and EBNA‐1 seroreactivities was observed in study participants above the median age of 24.9 years (attributable proportion due to interaction = 0.45). This finding supports the hypothesis that HHV‐6A and EBV infections interact in MS development. ANN NEUROL 2024;96:302–305

Funder

Vetenskapsrådet

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ana.27009

Reference10 articles.

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1. Integrating genetic and proteomic data to elucidate the association between immune system and blood-brain barrier dysfunction with multiple sclerosis risk and severity;Journal of Affective Disorders;2024-10

2. Additive effects of EBV and HHV-6A on MS risk;Nature Reviews Neurology;2024-07-09