Affiliation:
1. Key Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences Sichuan University 610064 Chengdu China
2. Luzhou Pinchuang Technology Co., Ltd. (National Engineering Research Center of Solid‐state Brewing) 646000 Luzhou China
3. Key Laboratory of Irradiation Preservation of Sichuan Province Sichuan Institute of Atomic Energy Sichuan Chengdu China
4. Core Laboratory, School of Medicine Sichuan Provincial People's Hospital Affiliated to University of Electronic Science and Technology of China 610072 Chengdu China
Abstract
AbstractTartary buckwheat flavonoids have a variety of effects on anti‐inflammatory, anti‐oxidation, as well as anti‐tumor and are valuable for academic research and industrial application. Helicobacter pylori (H. pylori) infection is associated with various gastrointestinal diseases in humans, and an increase in its resistance has led to the failure of many drugs. In this study, we quantified the main monomers of tartary buckwheat (Fagopyrum Tataricum (L.) Gaertn.) bran flavonoids extract through HPLC analysis. Then, we investigated the anti‐H. pylori activity and the effect on cell inflammation of tartary buckwheat flavonoids extract and its four main flavonoid monomers (rutin, quercetin, kaempferol, and nicotiflorin). The results showed that tartary buckwheat flavonoids extract and its four flavonoid monomers could inhibit the growth of H. pylori and down‐regulate the expression of proinflammatory factors IL‐6, IL‐8, and CXCL‐1 in H. pylori‐induced GES‐1 cells. Moreover, we also confirmed that tartary buckwheat flavonoids extract could reduce the expression of virulence factor gene of H. pylori. In summary, tartary buckwheat can alleviate the cell inflammation induced by H. pylori, which provides a theoretical basis for the development of tartary buckwheat healthcare products.