Affiliation:
1. The Second Clinical Medical School Nanchang University Nanchang China
2. Department of Blood Transfusion The Second Affiliated Hospital of Nanchang University Nanchang China
3. Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University Jiangxi Province Key Laboratory Medicine Nanchang China
4. The Ophthalmology & Optometry School Nanchang University Nanchang China
5. School of Pharmacy Nanchang University Nanchang China
6. School of Public Health Nanchang University Nanchang China
Abstract
AbstractBackgroundLung cancer (LC) is the leading cause of cancer‐related deaths worldwide. Tumor marker (TM) detection can indicate the existence and growth of a tumor and has therefore been used extensively for diagnosing LC. Here, we conducted a bibliometric analysis to examine TM‐related publications for LC diagnosis to illustrate the current state and future trends of this field, as well as to identify additional promising TMs with high sensitivity.MethodsPublications regarding TMs in LC diagnosis were downloaded from the Web of Science Core Collection. CiteSpace was applied to perform a bibliometric analysis of journals, cocitation authors, keywords, and references related to this field. VOSviewer was used to generate concise diagrams about countries, institutions, authors, and keywords. Changes in the TM research frontier were analyzed through citation burst detection.ResultsA total of 990 studies were analyzed in this work. The collaboration network analysis revealed that the People's Republic of China, Yonsei University, and Molina R were the most productive country, institution, and scholar, respectively. Additionally, Molina R was the author with the most citations. The National Natural Science Foundation of China was the largest funding source. “Carcinoembryonic antigen (CEA) as tumor marker in lung cancer” was the top reference with the most citations, Lung Cancer was the core journal, and “serum tumor marker” experienced a citation burst over the past 5 years.ConclusionThis bibliometric analysis of TMs in LC diagnosis presents the current trends and frontiers in this field. We summarized the research status of this field and the methods to improve the diagnostic efficacy of traditional serum TMs, as well as provided new directions and ideas for improving the LC clinical detection rate. Priority should be given to the transformation of computer‐assisted diagnostic technology for clinical applications. In addition, circulating tumor cells, exosomes, and microRNAs were the current most cutting‐edge TMs.
Funder
Education Department of Jiangxi Province
Subject
Pharmacology (medical),Cancer Research,Pharmacology, Toxicology and Pharmaceutics (miscellaneous),Drug Discovery,Oncology