A novel histochemistry assay to assess and quantify focal cytochromecoxidase deficiency

Author:

Simard Marie-Lune1,Mourier Arnaud12,Greaves Laura C34,Taylor Robert W45,Stewart James B1ORCID

Affiliation:

1. Max Planck Institute for Biology of Ageing; Cologne Germany

2. CNRS, Université de Bordeaux; Institut de Biochimie et Génétique Cellulaires; UMR5095, Bordeaux France

3. Newcastle University LLHW Centre for Ageing and Vitality; Newcastle University; Newcastle upon Tyne UK

4. Wellcome Centre for Mitochondrial Research, Institute of Neuroscience; Newcastle University; Newcastle upon Tyne UK

5. NHS Highly Specialised Mitochondrial Diagnostic Laboratory; Newcastle upon Tyne Hospitals NHS Foundation Trust; Newcastle upon Tyne UK

Funder

Biotechnology and Biological Sciences Research Council

Medical Research Council - UK

Wellcome Centre for Mitochondrial Research

Newcastle University Centre for Ageing and Vitality

Max-Planck-Gesellschaft

Medical Research Council (MRC) Centre for Translational Research in Neuromuscular Disease

University of Kentucky

Lily Foundation

UK NIHR Biomedical Research Centre for Ageing

Newcastle upon Tyne Foundation Hospitals NHS Trust

MRC/EPSRC Molecular Pathology Node

UK NHS Highly Specialised Service for Rare Mitochondrial Disorders of Adults and Children

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference48 articles.

1. Mitochondrial disease in childhood: mtDNA encoded;Saneto;Neurotherapeutics,2012

2. Genetic and biochemical intricacy shapes mitochondrial cytopathies;Turnbull;Neurobiol Dis,2015

3. Mitochondrial diseases;Gorman;Nat Rev Dis Primers,2016

4. Focal deficiency of cytochrome-c-oxidase in skeletal muscle of patients with progressive external ophthalmoplegia. Cytochemical-fine-structural study;Müller-Höcker;Virchows Arch A Pathol Anat Histopathol,1983

5. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study;Müller-Höcker;Am J Pathol,1989

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