Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, t-Reference-Cited by-同舟云学术

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Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, t

Published:2017-09-21 Issue:5 Volume:5 Page:e00357
ISSN:2052-1707
Container-title:Pharmacology Research & Perspectives
language:en
Short-container-title:Pharmacol Res Perspect

Author:

Elsby Robert¹^ORCID,Chidlaw Stephen¹,Outteridge Samuel¹,Pickering Sarah¹,Radcliffe Amy¹,Sullivan Rebecca¹,Jones Hayley¹,Butler Philip¹

Affiliation:

1. Drug Transporter Sciences; Cyprotex Discovery Ltd (an Evotec company); No 24 Mereside, Alderley Park Macclesfield Cheshire United Kingdom

Funder

Cyprotex Discovery Ltd

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

Reference41 articles.

1. Review of P-gp inhibition data in recently approved new drug applications: utility of the proposed [I1]/IC50 and [I2]/IC50 criteria in the P-gp decision tree;Agarwal;J Clin Pharmacol,2013

2. Bactrim™ www.accessdata.fda.gov/scripts/cder/daf/

3. Optimizing the in vitro and clinical assessment of drug interaction risk by understanding co-medications in patient populations;Bloomer;Expert Opin Drug Metab Toxicol,2013

4. Metformin and cimetidine: physiologically based pharmacokinetic modelling to investigate transporter mediated drug-drug interactions;Burt;Eur J Pharm Sci,2016

5. Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction;Cheng;Biochem Pharmacol,1973

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