Affiliation:
1. Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, School of Pharmacy Shihezi University Shihezi 832002 P. R. China
2. Department of Pharmacognosy, School of Pharmacy Fudan University Shanghai 201203 P. R. China
Abstract
AbstractTwo rare jatropham lactam derivatives, named as fulvanines J−K (1‐2), together with six known pyrrole alkaloids, 5,5′‐oxydi(3‐methyl‐3‐pyrrolin‐2‐one) (3), (−)‐5‐hydroxy‐3‐methyl‐3‐pyrrolin‐2‐one (jatropham) (4), (±)‐5‐O‐methyljatropham (5), perlolyrine (6), butyl‐2‐formyl‐5‐(hydroxymethyl)‐1H‐pyrrole‐1‐butanoate (7), and hemerocallisamine II (8), were isolated from the flower of Hemerocallis fulva. Their structures were elucidated on the basis of spectroscopic methods and compared with the NMR spectra data in the literature. All compounds were evaluated for their anti‐complementary activity in vitro, and compounds 1, 4, and 6 exhibited anti‐complement effect with CH50 values from 0.61 to 1.42 mM.
Funder
National Natural Science Foundation of China
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Reference19 articles.
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