Affiliation:
1. College of Agronomy and Biotechnology Yunnan Agricultural University Kunming 650201 China
2. Limei Tibetan Medicine Hospital Liwuqi 855600 China
3. School of Pharmacy Chongqing Three Gorges Medical Colleges Chongqing 404120 China
4. Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area Chongqing 404120 China
Abstract
AbstractAlkaloids are natural products that occur widely in many herbal plants. Anisodamine, widely present in the Solanaceae family, is an alkaloid extracted from the roots of the Anisodus tanguticus Maxim. It is an antagonist to M‐choline receptors and exhibits diverse pharmacological effects, such as cholinolytic effect, calcium antagonist effect, anti‐oxygenation effect. Anisodamine, a prominent constituent of the tropine alkaloid family, exhibits a range of pharmacological effects akin to those of atropine and scopolamine. owing to its low toxicity and moderate efficacy in clinical to wide applications, especially for varieties of shock treatment. However, there remains a dearth of research regarding the in vivo pharmacokinetics, mechanism of action, and toxicity of anisodamine. Consequently, this paper provides a comprehensive review of the anti‐shock effects, toxicity, and pharmacokinetic characteristics of anisodamine to increase the understanding of its medicinal value, and provide reference and inspiration for the clinical application and further in‐depth research of anisodamine.