Three Undescribed Protoilludane‐Type Sesquiterpene Aryl Esters from <i>Armillaria gallica</i>-Reference-Cited by-同舟云学术

Three Undescribed Protoilludane‐Type Sesquiterpene Aryl Esters from Armillaria gallica

Published:2024-08-19 Issue:9 Volume:21 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Zhang Jing‐Jing¹²,Yang Song‐Xue¹,Zhang Xing‐Jie¹,Li Na¹,He Xiao‐Ting¹,Xiao Wei‐Lie¹²^ORCID,Cheng Li‐Jun³,Li Xiao‐Li¹

Affiliation:

1. Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of Education Yunnan Characteristic Plant Extraction Laboratory Yunnan Key Laboratory of Research and Development for Natural Products State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Institute of International Rivers and Eco-Security School of Pharmacy and School of Chemical Science and Technology Yunnan University Kunming 650500 China

2. Southwest United Graduate School Kunming 650092 China

3. Yunnan Key Laboratory of Gastrodia and Fungi Symbiotic Biology Zhaotong University Zhaotong 65700 China

Abstract

AbstractThree previously undescribed protoilludane‐type sesquiterpene aryl esters, armillanals A−C (1–3), along with seven known ones (4–10) were obtained from Armillaria gallica Marxm. & Romagn. Compounds 1 and 2 were a rare class of sesquiterpenes featuring the Δ2(3) and Δ12(13)‐protoilludane skeleton. Their structures were established by extensive spectroscopic methods. Based on electronic circular dichroism (ECD) calculations, the absolute configurations of three new compounds (1–3) were determined. The anti‐inflammatory activity of compounds 1–10 was screened and compound 3 could dose‐dependently decrease the level of lactate dehydrogenase, showing IC50 value of 4.525 μM.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202401303

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