Affiliation:
1. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 P. R. China
2. School of Chinese Materia Medica Guangdong Pharmaceutical University Guangzhou 510006 P. R. China
3. Institute for Inheritance-Based Innovation of Chinese Medicine School of Pharmaceutical Sciences Health Science Center Shenzhen University Shenzhen 518060 P. R. China
Abstract
AbstractFour new germacrane‐type sesquiterpenes commiphoranes M1‐M4 (1‐4) together with eighteen sesquiterpenes were isolated from the Resina Commiphora. The structures and relative configurations of new substances were determined by using spectroscopic methods. Biological activity investigation revealed that nine compounds including 7, 9, 14, 16, (+)‐17, (−)‐17, 18, 19, and 20 could induce the apoptosis of prostate cancer originated PC‐3 cells, through classic apoptosis signaling pathway, even using flow cytometry showed that the compound (+)‐17 caused apoptosis of PC‐3 cells more than 40 %, suggesting their potential therapeutic application in the development of novel drugs against prostate cancer.
Funder
National Science Fund for Distinguished Young Scholars
Shenzhen Fundamental Research Program
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
1 articles.
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