Affiliation:
1. Department of Chemistry Faculty of Sciences Egerton University P.O. Box 536, 20115 Egerton Kenya
2. Department of Microbial Drugs Helmholtz Centre for Infection Research (HZI) German Centre for Infection Research (DZIF) Partner Site Hannover-Braunschweig Inhoffenstrasse 7 38124 Braunschweig, Germany
3. Department of Physical Sciences University of Embu Embu 6-60100 Kenya
Abstract
AbstractDuring the course of our ongoing studies on the secondary metabolism of cultures of Basidiomycota, a new meroterpenoid named 10, 15‐dihydroxydihydromelleolide (1) was isolated along with the known armillaridin (2) and arnamiol (3) from cultures of the rare saprotrophic species, Desarmillaria ectypa. These are the first secondary metabolites that were ever isolated from the latter species. A concurrently studied strain of the common pathogenic A. mellea yielded other melleolides, with 5’‐O‐methylmelledonal (4), melledonal C (5), 10 α‐hydroxydihydromelleolide (6) and melledonal (7). The chemical structures were elucidated using 1D and 2D NMR spectroscopy and high‐resolution electrospray ionization mass spectrometry (HR‐ESI‐MS). All compounds were studied for their antimicrobial and cytotoxic effects against a panel of microbes and mammalian cell lines, and the results are also reported.