Terpenoids with Cytotoxic Activity from Roots of Ardisia crispa

Abstract

AbstractThree new terpenoids, ardisiacrispins G‐I (1, 4 and 8), and eight known compounds, cyclamiretin A (2), psychotrianoside G (3), 3‐hydroxy‐β‐damascone (5), megastigmane (6), corchoionol C (7), zingiberoside B (9), angelicoidenol (10), trans‐linalool‐3,6‐oxide‐β‐D‐glucopyranoside (11) were isolated from the roots of Ardisia crispa. The chemical structures of all isolated compounds were elucidated by extensive spectroscopic analyses, such as HR‐ESI‐MS, 1D and 2D NMR spectra. Ardisiacrispin G (1) represents the oleanolic‐type scaffold featuring a rare 15,16‐ epoxy system. All compounds were evaluated for the cytotoxicity against two cancer cell lines (U87 MG and HepG2) in vitro. Compounds 1, 8 and 9 exhibited moderate cytotoxic activity with IC50 values ranging from 7.6±1.1 to 28.8±3.2 μM.