Synthesis, Anticancer Evaluation and <i>in Silico</i> Studies of 1,4‐Dihydropyridines-Reference-Cited by-同舟云学术

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Published:2023-07-20 Issue:8 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Merugu Santha Kumari¹²,Krishnan K V. B. R.¹,Kumar K Ravi³,Ansari Siddique Akber⁴,Ansari Irfan Aamer⁵,Bollikolla Hari Babu¹⁶⁷^ORCID

Affiliation:

1. Department of Chemistry Acharya Nagarjuna University, NNagar Guntur 522510, AP- India

2. Department of Chemistry Government Degree college Rajhamundry 533524, AP- India

3. Department of Pharmaceutical Chemistry and Phytochemistry Nirmala College of Pharmacy, Atmakur, Mangalagiri Guntur 522302, AP- India

4. Department of Pharmaceutical chemistry College of Pharmacy King Saud University PO Box.2457 Riyadh 11451 Saudi Arabia

5. Department of Drug Science & Technology University of Turin 10124 Turin Italy

6. Department of Nanotechnology Acharya Nagarjuna University, NNagar Guntur 522510 AP India

7. Department of Chemistry Andhra Kesari University Ongole, Prakasam Dist 523 001, AP- India

Abstract

AbstractAn efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in‐silico docking studies were conducted to understand the structure‐based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds.

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202201158

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