Affiliation:
1. Department of Basic Sciences and Health Hemp Institute Yozgat Bozok University Yozgat Turkey
2. Department of Molecular Biology and Genetics Faculty of Science Bartin University Bartin Turkey
3. Department of Genetics and Bioengineering Rafet Kayış Faculty of Engineering Alanya Alaaddin Keykubat University Antalya Turkey
4. Department of Medical Services and Techniques Tokat Vocational School of Health Services Tokat Gaziosmanpaşa University Tokat Turkey
5. Department of Veterinary Medicine Laboratory and Veterinary Health Program Artova Vocational School Tokat Gaziosmanpaşa University Tokat Turkey
6. Department of Chemistry Faculty of Arts and Sciences Yozgat Bozok University Yozgat Turkey
Abstract
AbstractThis study investigated the biological activity of the silver coordination compound K‐22. The IC50 values of K‐22 on cancer cell lines range from 0.797 μg/mL to 3.426 μg/mL, indicating that K‐22 might preferably inhibit A549, Saos‐2, MCF‐7, and HT‐29 cell proliferation and thus have better therapeutic activity. Furthermore, K‐22 stimulated apoptosis via up‐regulation of the mRNA and protein expression level of Bax/Bcl‐2 ratio in A549, Saos‐2, MCF‐7, and HT‐29. K‐22 exhibited antimicrobial activity against S. aureus, E. faecalis, K. pneumonia, P. aeruginosa, C. utilis, and C. albicans. Experimental results show that the compound has inhibitory potential with an IC50 value of 178.10 μM for the BChE (butyrylcholinesterase) enzyme, which has a vital role in the progression of Alzheimer's disease. As a result, compound K‐22 exhibits a strong potential for medical use due to its anticancer, antibacterial, antifungal, and anti‐Alzheimer properties.
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering