Affiliation:
1. State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences 555 Zuchongzhi Road Shanghai 201203 People's Republic of China
2. School of Chinese Materia Medica Nanjing University of Chinese Medicine 138 Xianlin Road Nanjing 210023 People's Republic of China
3. Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery 198 East Binhai Road Yantai Shandong 264117 People's Republic of China
Abstract
AbstractCroton sublyratus (Euphorbiaceae) is a traditional medicinal plant used by the Thai populace to treat helminthic infections and dermatologic conditions. In present study, eight new labdane‐type diterpenoids, crotonoids A–H (1–8) and one known analogue (9) were isolated from the aerial parts of C. sublyratus. Compounds 6 and 7 belong to the rare class of 14,15‐dinor‐labdane diterpenoids. Compound 8 exhibited a rare 14,15,17‐trinor‐labdane skeleton. The structures of all these diterpenoids were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single‐crystal X‐ray diffraction analysis. Compound 9 exhibited moderate anti‐inflammatory activity via the inhibition of NO production in lipopolysaccharide‐induced RAW 264.7 cells.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China