Brønsted Acid Promoted Facile Synthesis of Benzoacridines from Aromatic Aldehydes and <i>N</i>‐Phenyl Naphthylamines-Reference-Cited by-同舟云学术

Brønsted Acid Promoted Facile Synthesis of Benzoacridines from Aromatic Aldehydes and N‐Phenyl Naphthylamines

Published:2023-03-22 Issue:4 Volume:20 Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Chen Ting¹,Tan Bin¹,Huang Zhi¹,Mao Guojiang²,Chen Shanping¹,Deng Guo‐Jun¹^ORCID

Affiliation:

1. Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry Xiangtan University Xiangtan 411105 P. R. China

2. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang Xinxiang 453007 P. R. China

Abstract

AbstractA facile method for the rapid synthesis of benzoacridines has been described. This protocol promoted by p‐toluenesulfonic acid starts from aromatic aldehydes and N‐phenyl naphthylamines, affording a variety of benzoacridines in 30–90 % yields under metal‐free conditions. The present approach involves a cascade of condensation, Friedel‐Crafts alkylation, annulation and dehydroaromatization in one pot.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202300122

Reference43 articles.

1. Redesigning the DNA-Targeted Chromophore in Platinum-Acridine Anticancer Agents: A Structure-Activity Relationship Study

2. Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents

3. Design, Synthesis, Antimicrobial, and Anticancer Activities of Acridine Thiosemicarbazides Derivatives

4. Synthesis and biological evaluation of novel benzo[ c ]acridine‐diones as potential anticancer agents and tubulin polymerization inhibitors

5. Benzo[a]acridinylmethyl esters as pH sensitive fluorescent photoactive precursors: synthesis, photophysical, photochemical and biological applications