Affiliation:
1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development Liaoning Province Engineering Research Center of Natural Medicine Active Molecule Research & Development Liaoning Province Key Laboratory of Natural Bioactive Compounds Discovery & Modification Shenyang School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 Liaoning China
Abstract
AbstractIn this phytochemical investigation, two pairs of new phenylethanoid derivative enantiomers (1a/1b and 2a/2b), a new phenylethanoid derivative 3b, and seven known compounds (3a, 4–9) were isolated from the leaves of Picrasma quassioides. Spectroscopic techniques were used for the elucidation of their chemical structures, and the absolute configurations were determined by a comparison between the experimental and calculated ECD data, as well as the application of Snatzke's method. Compounds (1a/1b–3a/3b) were measured for their production of NO levels in LPS‐induced BV‐2 microglial cells. The results showed that all compounds exhibited potential inhibitory effects, and compound 1a showed stronger activity than the positive control.
Funder
Liaoning Revitalization Talents Program
Shenyang Pharmaceutical University
Subject
Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering
Cited by
3 articles.
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