Cytotoxic withanolides from the leaves of Datura stramonium L.

Author:

Pan Juan1,Liu Yan1,Li Xin‐Yuan1,Wang Si‐Yi1,Wu Jia‐Tong1,Li Meng‐Meng1,Guan Wei1,Mohammed Algradi Adnan1,Kuang Hai‐Xue1,Yang Bing‐You1ORCID

Affiliation:

1. Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine Ministry of Education Harbin 150040 China

Abstract

AbstractSix novel withanolides, along with nine known related compounds were isolated from the leaves of Datura stramonium L. The structures and absolute configurations of the new withanolides were elucidated by employing various spectral techniques and comparing them with those previously reported in the literature. In addition, four withanlides demonstrated interesting cytotoxic activity on LN229 cells with IC50<20 μM.

Publisher

Wiley

Subject

Molecular Biology,Molecular Medicine,General Chemistry,Biochemistry,General Medicine,Bioengineering

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