Antivenom Properties and Chemical Profiling via Molecular Networking of <i>Mimosa gracilis</i> Extracts-Reference-Cited by-同舟云学术

Antivenom Properties and Chemical Profiling via Molecular Networking of Mimosa gracilis Extracts

Published:2024-09-09 Issue: Volume: Page:
ISSN:1612-1872
Container-title:Chemistry & Biodiversity
language:en
Short-container-title:Chemistry & Biodiversity

Author:

Alexandre Gerso P.¹,da Silva Marcia M.¹,Clemente Alan D.²,Torres Ana M.³,Magalhães Marta R.⁴,Pasqualotto Severino Vanessa G.¹

Affiliation:

1. Laboratório de Produtos Naturais e Síntese Orgânica Instituto de Química, Universidade Federal de Goiás CEP 74690–900 Goiânia, GO Brazil

2. Laboratório de Química Orgânica Instituto Federal de Educação, Ciência e Tecnologia de Goiás CEP 74.968-755 Aparecida de Goiânia, GO Brazil

3. Laboratorio de Productos Naturales Prof. Armando Ricciard Universidad Nacional del Nordeste CP 3400 Corrientes Argentina

4. Centro de Estudos e Pesquisas Biológicas Escola de Ciências Médicas e da Vida Pontifícia Universidade Católica de Goiás CEP 74.605-010 Goiânia, GO Brazil

Abstract

AbstractThe species Mimosa gracilis var. capillipes (Benth.) Barneby is used for its antivenom properties in the Coqueiros community, municipality of Catalão, state of Goiás. This study focused on three varieties: M. gracilis Benth. var. gracilis, M. gracilis var. capillipes (Benth.) Barneby, and M. gracilis var. invisiformis Barneby. The chemical profiles of extracts from these varieties were analysed using molecular networking through liquid chromatography with tandem mass spectrometry. Additionally, the study investigated the inhibitory potential of these three varieties against the proteolytic, coagulant, and phospholipase activities of Bothrops and Crotalus venoms. In vitro results confirmed the antivenom potential of nine extracts. Remarkably, the ethanolic extracts of roots from M. gracilis var. capillipes (Benth.) Barneby and the leaves from M. gracilis Benth. var. gracilis exhibited 100 % inhibition of the tested activities. The study also revealed 19 annotated compounds through molecular networking, reported for the first time in the species M. gracilis.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202400689

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